Microstructural evolution and dynamic recrystallization (DRX) mechanisms of a Ti-48Al-2Cr-2Nb (at.%) alloy prepared by selective electron beam melting (SEBM) during hot deformation at 1150 °C and 0.1 s-1 were investigated by hot compression tests, optical microscope (OM), scanning electron microscope (SEM), electron back-scattered diffraction (EBSD) and transmission electron microscope (TEM). The results show that the initial microstructure of the as-SEBMed alloy exhibits layers of coarse γ grains and fine γ+α2+(α2/γ) lamellar mixture grains alternately along the building direction. During the early stage of hot deformation, deformation twins tend to form within the coarse grains, facilitating subsequent deformation, and a small number of DRX grains appear in the fine-grained regions. With the increase of strain, extensive DRX grains are formed through different DRX mechanisms in both coarse and fine-grained regions, involving discontinuous dynamic recrystallization mechanism (DDRX) in the fine-grained regions and a coexistence of DDRX and continuous dynamic recrystallization (CDRX) in the coarse- grained regions.